Aims & Projects
Aims
We will pursue the following aims in myelofibrosis:
Aim 1. Dissect mechanisms of fibrotic transformation in myelofibrosis
Aim 2. Understand the changes leading to loss of normal hematopoiesis in myelofibrosis
Aim 3. Identify novel cellular and molecular targets in myelofibrosis
Projects
P1: Dissecting the bone marrow stromal contribution to myelofibrosis
P2: Interaction of the MPN clone and its microenvironment via the JAK1-STAT3 axis
P3: Dissecting mechanisms in the fibrotic reprogramming of the bone marrow niche in myelofibrosis
P4: The impact of human megakaryocytes in JAK2V617F and CALRmut induced myelofibrosis
P5: Cellular aging in myeloproliferative neoplasms
P6: Mechanisms of IFN-alpha (IFNa) in MPN-associated myelofibrosis
SP1: Transcriptional analysis in defined cell types and single cells