Publications

A list of all publications submitted by members of this CRU can be found here.

For an overview of their scientific work, please refer to the PI’s website or their respective reference list linked below.

Univ.-Prof. Dr. med. Rafael Kramann (P1)

Prof. Dr. rer. nat. Gerhard Müller-Newen (P2)

Dr. rer. nat. Mirle Schemionek-Reinders (P2)

Univ.-Prof. Dr. med. Rebekka Schneider (P3)

Dr. rer. nat. Nicolas Chatain (P4)

Univ.-Prof. Dr. rer. nat. Martin Zenke (P4)

Univ.-Prof. Dr. med. Tim H. Brümmendorf (P5)

Univ.-Prof. Dr. med. Dr. rer. nat. Wolfgang Wagner (P5)

Univ.-Prof. Dr. med. Steffen Koschmieder (P6)

Univ.-Prof. Dr. rer. nat. Ivan Costa (SP1)

Project-related publications
Articles published by outlets with scientific quality assurance, book publications, and works accepted for publication but not yet published. (*equal contribution)

  1. Baumeister J, Maié T, Chatain N, Gan L, Weinbergerova B, de Toledo MAS, Eschweiler J, Maurer A, Mayer J, Kubesova B, Racil Z, Schuppert A, Costa I, Koschmieder S, Brümmendorf TH, Gezer D. Early and late stage MPN patients show distinct gene expression profiles in CD34+ cells. Ann Hematol. 2021 Dec;100(12):2943-2956.
     
  2. Boehnke J, Atakhanov S, Toledo MAS, Schüler HM, Sontag S, Chatain N, Koschmieder S, Brümmendorf TH, Kramann R, Zenke M. CRISPR/Cas9 mediated CXCL4 knockout in human iPS cells of polycythemia vera patient with JAK2 V617F mutation. Stem Cell Res. 2021 Aug;55:102490.
     
  3. Božić T, Kuo C-C, Hapala J, Franzen J, Eipel M, Platzbecker U, Kirschner M, Beier F, Jost E, Thiede C, Wagner W. Investigation of Measurable Residual Disease in Acute Myeloid Leukemia by DNA Methylation Patterns. Leukemia. 2022 Jan;36(1):80-89
     
  4. Cypris O, Eipel O, Franzen J, Rösseler C, Tharmapalan V, Kuo CC, Vieri M, Nikolić M, Kirschner M, Brümmendorf TH, Zenke M, Lampert A, Beier F, Wagner W. PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. Clinical Epigenetics (2020) 12: 125.
     
  5. Franzen J, Nüchtern S, Tharmapalan V, Vieri M, Nikolic M, Han Y, Balfanz P, Marx N, Dreher M, Brümmendorf TH, Dahl E, Beier F, Wagner W. Epigenetic clocks are not accelerated in COVID-19 patients. International Journal of Molecular Sciences. 2021 Aug 27;22(17):9306.
     
  6. Gecht J, Tsoukakis I, Kricheldorf K, Stegelmann F, Klausmann M, Griesshammer M, Schulz H, Hollburg W, Göthert JR, Sockel K, Heidel FH, Gattermann N, Maintz C, Al-Ali HK, Platzbecker U, Hansen R, Hänel M, Parmentier S, Bommer M, Pahl HL, Lang F, Kirschner M, Isfort S, Brümmendorf TH, Döhner K, Koschmieder S. Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry. Cancers (Basel). 2021 Aug 13;13(16):4086.
     
  7. Gleitz HFE*, Dugourd AJF*, Leimkühler NB*, Snoeren IAM, Fuchs SNR, Menzel S, Ziegler S, Kröger N, Triviai I, Büsche G, Kreipe H, Banjanin B, Pritchard JE, Hoogenboezem R, Bindels EM, Schumacher N, Rose-John S, Elf S, Saez-Rodriguez J, Kramann R*, Schneider RK*. Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN. Blood. 2020 Oct 29;136(18):2051-2064.
     
  8. Han Y, Franzen J, Stiehl T, Gobs M, Kuo CC, Nikolic M, Hapala J, Koop BE, Strathmann K, Ritz-Timme S, Wagner W. New Targeted Approaches for Epigenetic Age Predictions. BMC Biology (2020) 18: 71.
     
  9. Han Y, Nikolić M, Gobs M, Franzen J, de Haan G, Geiger H, Wagner W. Targeted methods for epigenetic age-predictions in mice. Scientific Reports (2020) 10: 22439.
     
  10. Hollmann J, Brecht J, Goetzke R, Franzen J, Selich A, Schmidt M, Eipel M, Ostrowska A, Hapala J, Fernandez-Rebollo E, Müller-Newen G, Rothe M, Eggermann T, Zenke M, Wagner W. Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells. Stem Cell Res Ther. 2020 Mar 5;11(1):105
     
  11. Jansen J*, Reimer KC*, Nagai JS*, Varghese FS, Overheul GJ, de Beer M, Roverts R, Daviran D, Fermin LAS, Willemsen B, Beukenboom M, Djudjaj S, von Stillfried S, van Eijk LE, Mastik M, Bulthuis M, Dunnen WD, van Goor H, Hillebrands JL, Triana SH, Alexandrov T, Timm MC, van den Berge BT, van den Broek M, Nlandu Q, Heijnert J, Bindels EMJ, Hoogenboezem RM, Mooren F, Kuppe C, Miesen P, Grünberg K, Ijzermans T, Steenbergen EJ, Czogalla J, Schreuder MF, Sommerdijk N, Akiva A, Boor P, Puelles VG, Floege J, Huber TB; COVID Moonshot consortium, van Rij RP, Costa IG*, Schneider RK*, Smeets B*, Kramann R*. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. Cell Stem Cell. 2022 Feb 3;29(2):217-231.e8.
     
  12. Kenswil KJG, Pisterzi P, Sánchez-Duffhues G, van Dijk C, Lolli A, Knuth C, Vanchin B, Jaramillo AC, Hoogenboezem RM, Sanders MA, Feyen J, Cupedo T, Costa IG, Li R, Bindels EMJ, Lodder K, Blom B, Bos PK, Goumans MJ, Ten Dijke P, Farrell E, Krenning G, Raaijmakers MHGP. Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation. Cell Stem Cell. 2021 Apr 1;28(4):653-670.e11
     
  13. Kuppe C*, Ibrahim MM*, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Decoding myofibroblast origins in human kidney fibrosis. Nature. 2021 Jan;589(7841):281-286.
     
  14. Leimkühler NB*, Gleitz HFE*, Ronghui L*, Snoeren IAM, Fuchs SNR, Nagai JS, Banjanin B, Lam KH, Vogl T, Kuppe C, Stalmann USA, Büsche G, Kreipe H, Gütgemann I, Krebs P, Banz Y, Boor P, Tai EW, Brümmendorf TH, Koschmieder S, Crysandt M, Bindels E, Kramann R*, Costa IG*, Schneider RK*. Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8.
     
  15. Olschok K*, Han L*, de Toledo MAS, Böhnke J, Graßhoff M, Costa IG, Theocharides A, Maurer A, Schüler HM, Buhl EM, Pannen K, Baumeister J, Kalmer M, Gupta S, Boor P, Gezer D, Brümmendorf TH, Zenke M, Chatain N*, Koschmieder S*. CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes. Stem Cell Rep. 2021 Nov 9;16(11):2768-2783
     
  16. Schmidt M, Maié T, Dahl E, Costa IG, Wagner W. Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites. BMC Biol. 2020 Nov 24;18(1):178
     
  17. Tillmann S, Olschok K, Schröder SK, Bütow M, Baumeister J, Kalmer M, Preußger V, Weinbergerova B, Kricheldorf K, Mayer J, Kubesova B, Racil Z, Wessiepe M, Eschweiler J, Isfort S, Brümmendorf TH, Becker W, Schemionek M, Weiskirchen R, Koschmieder S*, Chatain N*. The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR-ABL- and JAK2V617F-Positive MPN. Cancers (Basel). 2021 Aug 21;13(16):4210.
     
  18. Toledo MAS, Gatz M, Sontag S, Gleixner KV, Eisenwort G, Feldberg K, Hamouda AEI, Kluge F, Guareschi R, Rossetti G, Sechi AS, Dufva OMJ, Mustjoki SM, Maurer A, Schüler HM, Goetzke R, Braunschweig T, Kaiser A, Panse J, Jawhar M, Reiter A, Hilberg F, Ettmayer P, Wagner W, Koschmieder S, Brümmendorf TH, Valent P, Chatain N*, Zenke M*. Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis. Blood. 2021 Apr 15;137(15):2070-2084