Veranstaltungsort: CT² - Center for Teaching and Training Forckenbeckstraße 71, 52074 Aachen Veranstalter: Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation (Med. IV), Uniklinik

MARylation. Hydrolase activity seems essential for virus replication and immune evasion. In line with this we found PARP10 and PARP12 as being restrictive for virus replication. My team aims at deciphering [...] deciphering the importance of a functional viral macrodomain for viral replication and host cell modulation. Further we aim at determining how mono-ARTDs and MARylation contribute to an innate immune response using [...] and Tabarrini, O . (2022). Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem 237 , 114362. Luscher, B., Verheirstraeten

are prime targets for the treatment of a plethora of disorders. Our lab tries to understand how blood-forming stem cells (hematopoietic stem cells, HSCs) can be generated, in vitro, for future tailored cell- [...] many aspects of the developing embryo, this model is also very useful for studying the control of cell fate decisions crucial for blood stem cell development, in vitro. We are studying in vitro hematopoiesis [...] homologous recombination. Hence, patient-specific `autologous´ iPS-cells are especially attractive for gene repair and subsequent directed differentiation towards HSCs, in vitro. Because differentiation

, Vogt FJ. The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement? J Cell Mol Med. 2019; 23(1): 39-46. Cornelissen A , Jinnouchi H, Sakamoto A, et al. Evaluation [...] Sato Y, et al. COBRA PzFTM coronary stent in clinical and preclinical studies: setting the stage for new antithrombotic strategies? Future Cardiol. 2022 Mar; 18(3):207-217. doi: 10.2217/fca-2021-0057 [...] * (equal contribution), Florescu R, et al. The role of vitamin D3 as independent predicting marker for one-year mortality in patients with acute heart failure. J Clin Med. 2022 May 12;11(10):2733. doi:

Microgels for Stimulus-Triggered Drug Administration. Small . 2024:e2309912. 6. Ahmadian S, Lindsey PJ, Smeets HJM, van Tienen FHJ and van Zandvoort M. Spinning Disk Confocal Microscopy for Optimized and [...] T, van Zandvoort M, Benedikter BJ, Webers CAB, Reutelingsperger CPM and Gorgels T. A time window for rescuing dying retinal ganglion cells. Cell Commun Signal . 2024;22:88. 2. Werner MP, Kucikas V, Voss [...] as D, Vogt M, Hak S, Kiessling F, van Zandvoort M, Lammers T and Sofias AM. Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes. Adv Drug Deliv Rev . 2022;189:114528

Change the Universe… the search for extra-institutional life-forms On September 29 th 2023, we will continue our journey to change the universe of research at the Faculty of Medicine at the RWTH Aachen [...] "Ponttor". Registration: If you are interested in joining us, please register here . The deadline for registration is September, 13. Contact: If you have any questions feel free to reach out to us via

Das Spektrum der Klinik für Plastische Chirurgie, Hand- und Verbrennungschirurgie umfasst neben dem Bereich der Schönheitschirurgie ebenfalls die rekonstruktive Chirurgie sowie die Akutversorgung von Schwerstbrandverletzten.

Forschungsbereich Molekulare Mechanismen der Atherosklerose- und Re-Stenoseentstehung an der Medizinischen Klinik I

Thema Mutational Constraint Analysis Workflow for Overlapping Short Open Reading Frames and Genomic Neighbours CNVizard – a lightweight streamlit application for an interactive analysis of copy number variants

ukaachen de Publikationen zum Thema DDX41 germline variants causing donor cell leukemia indicate a need for further genetic workup in the context of hematopoietic stem cell transplantation. ldentification of [...] (YOU). Molecular Basis of Beckwith-Wiedemann Syndrome Spectrum with Associated Tumors and Consequences for Clinical Practice. Germline variants in DNA repair genes, including BRCA1/2, may cause familial my