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depolarizing influx of cations into cells upon binding of extracellular ATP and are interesting targets for new drugs. In the last years, significant advances in our understanding of the molecular function, [...] V/V 16 I mutation virtually abolished desensitization of the P2X3R (Fig. 1) and was indispensable for capturing the ATP-bound open-state X-ray crystal structure of the hP2X3R (Mansoor et al., 2016). Fig [...] n X-ray crystal structures of mammalian P2XRs, the human P2X3R (Mansoor et al., 2016) are crucial for the project. The open-, closed-, and desensitized-state hP2X3R structures provide an unprecedented

SCN AACHEN Prof. Dr. med. Ralf Hausmann rhausmann ukaachen de Ansprechpersonen im Scientific Center for Neuropathic Pain Aachen SCN AACHEN Stanislav Koulchitsky skoulchitsky ukaachen de Pauline Kinny pkinny

research is the identification of differential mechanisms for cardiovascular calcification and bone remodeling to detect novel therapeutic targets for vascular calcification, which do not negatively impact [...] German Cardiac Society. The scholarship provides financial support for medical students to perform an experimental medical doctoral thesis for one year. Carina will study the role of cytoskeletal reorganization [...] Student European Union’s Horizon 2020 ITN INTRICARE Lab Outing Lab Outing We are continuously looking for talented MD and PhD students with an interest in cardiovascular biology. If you are interested please

safe entry points for the intraocular insertion of larger objects. We will design insertion tools and perform tests in ex-vivo models as well as in in-vivo experiments (projects for medical students). [...] neuronal activity in visual cortex in the rd10 mouse model of retinitis pigmentosa. C5: Innovative tools for insertion and implantation of large microsystems into the vertebrate eye (MD projects) ( Walter, Baumgarten

bladder cancer ( “why do some bladder cancers look like skin cancers?” ), and b) potential targets for therapeutic interventions in squamous bladder cancers, e.g. EGFR (Epidermal Growth Factor Receptor) [...] urothelial carcinoma and its impact on disease course ( “why are some cancers fatal and others tolerable for some time?” ). Our group uses a wide range of tools based on tissues, cell culture, next generation [...] continuously extend our “toolbox” including new in vitro and ex vivo methodologies. We are also open for collaborative projects either in the field of bladder cancer or gastrointestinal diseases, and therefore

cardiovascular consequences of CKD. Progressive renal fibrosis leads to loss of function and the need for renal replacement therapy (dialyzes or renal transplantation). At the moment we still lack both, sensitive [...] r matrix, vascular sclerosis, and associated tubular atrophy and chronic inflammatory infiltrate. For comparison, at the right, normal kidney parenchyma is shown with only a small area with interstitial [...] of artificial intelligence (AI) and particularly machine learning (ML) and deep learning (DL) tools for preclinical as well as clinical histopathology (going beyond the kidney). A strong focus is on the

nrw/ ICU4Covid - Deliver Intensive Care Medicine Fit for the fight against COVID-19 to the EU citizen ICU4Covid - Deliver Intensive Care Medicine Fit for the fight against COVID-19 to the EU citizen. Das [...] Euro ins Leben gerufen. Das Hauptziel von ICU4Covid bestand darin, ein sogenanntes „Cyber-Physical for Telemedicine and Intensive Care Medical System“ (CPS4TIC) zur Bekämpfung von COVID-19 in der Inten

substitution with Psychobiotics Objective: To study the clinical efficacy of psychobiotics administration for 6 months in hospitalized adolescents with AN in comparison to a placebo and to healthy controls at

eCollection 2016 Apr.: “Underestimated associated features in CMT neuropathies: clinical indicators for the causative gene?” DOI: 10.1002/brb3.451