that inhibits translation initiation at the AUG by impeding 60S and 40S ribosomal subunits joining. We elucidated how HNRNPK interferes with 80S ribosome assembly. Three independent interaction screens c [...] 30778370 [4] Liepelt A, Naarmann-de Vries IS, Simons N, Eichelbaum K, Föhr S, Archer SK, Castello A, Usadel B, Krijgsveld J, Preiss T, Marx G, Hentze MW, Ostareck DH, Ostareck-Lederer A.: Identification of [...] erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining. Cell. 2001 Jan 26;104(2):281-90. doi: 10.1016/s0092-8674(01)00212-4. PMID: 11207

Klinkhammer BM, Ehling J, Djudjaj S, Drude NI, Daniel C, Amann K, Kramann R, Kim H, Saez-Rodriguez J, Weiskirchen R, Onthank DC, Botnar RM, Kiessling F, Floege J, Lammers T, Boor P: Elastin imaging enables

people with eating disor-ders. Cochrane Database Syst Rev. 2019;1:CD010827. Herpertz S, Herpertz-Dahlmann B, et al. S3-Leitlinie Diagnostik und Behandlung der Essstörungen. 2019. http://www.awmf.org/le [...] (2024). Anorexia nervosa-specific home treatment in children and adolescents and their families (the HoT study): a study protocol of a randomized, controlled, multicenter, open-label, parallel group superiority [...] s of inpatients with childhood vs. adolescent Anorexia Nervosa. Nutrients 2019;11(11). 15. Kircher T, Dempfle A, et al. Neurobiology of the Major Psychoses: A Translational Perspective on Brain Structure

Bodey AJ, Illig T, Leeming DJ, Karsdal MA, Tzankov A, Boor P, Kuehnel MP, Laenger FP, Verleden SE, Kvasnicka HM, Kreipe HH, Haverich A, Black SM, Walch A, Tafforeau P, Lee PD, Hoeper MM, Welte T, Seeliger B [...] Wagner WL, Jafree DJ, Bellier A, Werlein C, Kühnel MP, Boller E, Walker-Samuel S, Robertus JL, Long DA, Jacob J, Marussi S, Brown E, Holroyd N, Jonigk DD, Ackermann M, Lee PD. Imaging intact human organs [...] B, David S, Schuppan D*, Mentzer SJ*, Jonigk DD*. Lobular ischemia and fibrotic remodelling drive the fatal trajectory of pulmonary COVID-19. The Lancet - eBioMedicine. Volume 85, 2022 Oct; 04 https://doi

Bodey AJ, Illig T, Leeming DJ, Karsdal MA, Tzankov A, Boor P, Kuehnel MP, Laenger FP, Verleden SE, Kvasnicka HM, Kreipe HH, Haverich A, Black SM, Walch A, Tafforeau P, Lee PD, Hoeper MM, Welte T, Seeliger B [...] Wagner WL, Jafree DJ, Bellier A, Werlein C, Kühnel MP, Boller E, Walker-Samuel S, Robertus JL, Long DA, Jacob J, Marussi S, Brown E, Holroyd N, Jonigk DD, Ackermann M, Lee PD. Imaging intact human organs [...] B, David S, Schuppan D*, Mentzer SJ*, Jonigk DD*. Lobular ischemia and fibrotic remodelling drive the fatal trajectory of pulmonary COVID-19. The Lancet - eBioMedicine. Volume 85, 2022 Oct; 04 https://doi

Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med . 2006 [3] Fujitani, Y., Hibi, M., Fukada, T. et al. An alternative pathway [...] receptor encoded by the MPL proto-oncogene. The most frequent MPL mutation in the MPN context is a G to T transversion in exon 10 [1]. The resulting MPL W515L variant of the receptor is constitutively activated [...] domain in healthy cells [5]. In patients harboring the JAK2V617F mutation, which is defined by a G to T exchange in exon 14 of the JAK2 gene [4, 6], the interaction between JH1 and JH2 is disrupted, allowing

we focus on interdisciplinary cooperations, which are closely linked in the Graduate School ME3T ( www.me3t.rwth-aachen.de ). Methodisch liegt der Schwerpunkt insbesondere auf zellbiologischen Arbeiten [...] te ( Link ) Differential Regulation of Lung Endothelial Permeability in Vitro and in Situ . Uhlig, S., Yang, Y., Waade, J., Wittenberg, C., Babendreyer, A. and Kuebler, W. M. (2014). Cell. Physiol. Biochem [...] CX3CL1 Induction and Monocyte Cell Adhesion. Babendreyer, A. , Molls, L., Dreymueller, D., Uhlig, S. and Ludwig, A. (2017). Mediators Inflamm. 2017:1515389. The metalloproteinase ADAM15 is upregulated

Moellmann J, Klinkhammer BM, Droste P, Kappel B, Haj-Yehia E, Maxeiner S, Artati A, Adamski J, Boor P, Schütt K, Lopaschuk GD, Verma S, Marx N, Lehrke M.Biochim Biophys Acta Mol Basis Dis. 2020 Aug 1;186 [...] causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function.; Moellmann J, Krueger K, Wong DWL, Klinkhammer

vanderkuil@utwente.nl T: +31 6285 20493 in Aachen contact the Center for Robotics in Healthcare at robotics@ukaachen.de This project has received funding from the European Union’s Horizon 2020 research [...] efforts in development and implementation of digital technologies”, Stefano Stramigioli states. SME’s and midcaps located in Europe can apply for funding in open calls from summer 2019 until spring 2021

Das Institut für Physiologie hat die Lehre und Forschung in Physiologie zur Aufgabe. Wir beteiligen uns engagiert am Aachener Modellstudiengang Medizin, in dem bereits in den ersten Semestern eine bessere Verzahnung der vorklinischen und klinischen Elemente angestrebt wird.