rationszentrum ist organisatorisch dem Geschäftsbereich IT zugeordnet und befindet sich zur Zeit in den Räumlichkeiten des Geschäftsbereichs IT im Hauptgebäude der Uniklinik. Das Datenintegrationszentrum [...] RWTH Aachen. Betreten Sie den Haupteingang, wenden Sie sich nach links, folgen Sie der Gang B bis zum IT-Sekretariat. Contact - Administrative Office Datenintegrationszentrum Pauwelsstraße 30 52074 Aachen

employed a variety of different techniques to identify a regulatory domain at its cytosolic N-terminus. This domain binds with its amphiphilic a-helix to the plasma membrane and stabilizes the inactive state [...] BASIC is closely related to the epithelial Na+ channel (ENaC) and acid-sensing ion channels (ASICs). Its function is not understood yet. In our current study , which was published in the „Journal of Biological

Typically, the micro-environment of a tumour has a slightly acidic pH. It it therefore important to characterize acid sensors, like Acid-sensing ion channels (ASICs), in tumor cells. In our most recent [...] expresses functional ASIC1a. Public expression data confirmed expression of ASIC1a in medulloblastoma. It was already known that prolonged activation of ASIC1a can induce cell death. This was also the case [...] RIPK3 kinase. Our results confirm that ASIC1a is an important acid sensor in brain tumors and that its activation has the potential to induce cell death in tumor cells.

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Performanz und Zuverlässigkeit der IT-Infrastruktur sind für Unternehmen und auch eine Uniklinik wie unsere Herausforderung und Erfolgsfaktor zugleich. Um die Betriebssicherheit und Ausfallsicherheit von [...] Rheinland ein Kriterienkatalog zur Überprüfung der Normforderung der DIN EN 50600 entwickelt, dem sich die IT der Uniklinik RWTH Aachen erfolgreich gestellt hatte. In einem Audit wurde nunmehr der Nachweis erbracht [...] Anforderungen der Norm genügt. Dafür bedanke ich mich insbesondere beim Team des Geschäftsbereichs IT“, betont Peter Asché, Kaufmännischer Direktor der Uniklinik RWTH Aachen bei der Zertifikatsübereichung

Being away from the lab has its own challenges and merits, especially when playing and performing with the Wendland Symphony Orchestra. But it is fodder for the soul and a reminder of how intensely touching

hetero-oligomeric acid-sensing ion channel 1a/2a is broadly expressed in the brain and it has been shown that its blockade causes strong analgesia. In our paper "Acid-sensing ion channel (ASIC) 1a/2a [...] is uncommon for ion channels. The flexible composition of ASIC1a/2a presumably allows to fine tune its properties. Because drugs often bind at subunit interfaces, our results are important to understand

Therefore, it is considered as a potential therapeutic target for oxidative stress-induced pathologies, e.g. neurodegenerative diseases and chronic inflammatory processes. The elucidation of its molecular [...] molecular gating mechanism and its physiological function is therefore of great importance. The comparative study of species variants is a popular method to better elucidate the structure-function relationships

of retinal pigment epithelium in relation to its extracellular matrix. Jacopo uses interdisciplinary methods to understand retina biology, therefore its research will need imputes and support from students

the nerve of the patient. It necessitates substantial training of the medical doctors, limiting therefore the expansion of this technique in clinical environment despite its potential. The RASimAs research