Triviai I, Büsche G, Kreipe H, Banjanin B, Pritchard J, Hoogenboezem R, Bindels E, Schumacher N, Rose-John S, Elf S, Saez-Rodriguez J, Kramann R, Schneider RK . Increased CXCL4 expression in hematopoietic cells [...] Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira MS, Puelles V-G, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R#. Gli1+ mesenchymal [...] Schneider RK , Schenone M, Ventura Ferreira M, Kramann R, Joyce CE, Hartigan C Beier F, Brümmendorf TH, Germing U, Platzbecker U, Büsche G, Knüchel R, Chen MC, Waters CS, Chen E, Chu LP, Novina CD, Lindsley

Die Epileptologie in Aachen beschäftigt sich mit der Untersuchung von genetischen Epilepsien mit dem Ziel der Entwicklung neuer Therapiestrategien.

Uniklinik RWTH Aachen Institut für med. Mikrobiologie Referenzlabor für Streptokokken Etage 5, Flur 46, R2/R3 Pauwelsstr. 30 52074 Aachen

Publikationen – Humangenetische Beratungen in der Uniklinik RWTH Aachen

Whitman G, Ohkuma R, Brown T, Hatzakorzian R, Kristof A, Meybohm P, Mechanick J, Evans A, Yeh D, McDonald B, Chourdakis M, Jones P, Barton R, Tripathi R, Elke G, Liakopoulos O, Agarwala R, Lomivorotov V, [...] 2022;24(3):e34098. Published 2022 Mar 2. doi:10.2196/34098 Laaf E, Benstoem C , Rossaint R, Wendt S, Fitzner C, Moza A, Zayat R, Hill A, Heyland DK, Schomburg L, Goetzenich A, Stoppe C. High-dose supplementation [...] Jul 1;49(7):1169-1181. doi: 10.1097/CCM.0000000000004943 Petran J, Ansems K, Rossaint R, Marx G, Kalvelage C, Kopp R, Benstoem C , Brülls C. Effects of hypercapnia versus normocapnia during general anesthesia

concentration–response analysis and selectivity profiling revealed that ATA strongly inhibits the rP2X1 and rP2X3 receptors. Molecular docking studies, site-directed mutagenesis and concentration-response [...] indicated P2XRs (left) and molecular-docking of ATA and AF-219 (a known P2X3R antagonist) into the negative allosteric site of the hP2X3R. In another study we have demonstrated the inhibition of the human P2X3 [...] was the most effective antagonist. Due to their involvement in nociception, inhibition of hP2X3R and hP2X2/3R by micromolar concentrations of diclofenac, which are rarely reached in the human body, may play

Bartlett, E., Zaja, R., Ahel, I., and Matic, I. 2017 “Serine ADP-Ribosylation Depends on HPF1.” Molecular Cell 65, 932–940. Vyas, S., Matic, I., Uchima, L., Rood, J., Zaja, R., Hay, R. T., Ahel, I., and [...] * and Žaja, R.* (2021) ADP-ribosylation of RNA and DNA: from in vitro characterization to in vivo function. Nucleic Acids Res 2021 , 49, 3634-3650. Žaja, R*; Aydin G; Lippok, BE; Feederle, R; Lüscher, B; [...] Communications 5, 4426. Rosenthal, F.*, Feijs, K. L. H.*, Frugier, E., Bonalli, M., Forst, A. H., Imhof, R., Winkler, H. C., Caflisch, A., Hassa, P. O., Lüscher, B.*, and Hottiger, M. O.* 2013. Macrodomain-

J, Thevenod F, Roussa E, Rock J, and Schreiber R. (2011) Anoctamins. Pflugers Arch . 462, 195-208. Ousingsawat J, Mirza M, Tian Y , Roussa E, Schreiber R, Cook DI, and Kunzelmann K. (2011) Rotavirus toxin [...] Kunzelmann K, Kong esuphol P, Chootip K, Toledo C, Martins JR, Almaca J, Tian Y , Witzgall R, Ousingsawat J, and Schreiber R. (2011) Role of the Ca2+activated Cl-channels bestrophin and anoctamin in epithelial [...] epithelial cells. Biol Chem . 392, 125-134. Tian Y , Kongsuphol P, Hug M, Ousingsawat J, Witzgall R, Schreiber R, and Kunzelmann K. (2011) Calmodulin-dependent activation of the epithelial calcium-dependent chloride

De Angelis L, Heiser M, Ballanti M, Stoehr R, Goettsch C, Mavilio M, Artati A, Paoluzi OA, Adamski J, Mingrone G, Staels S, Burcelin R, Monteleone G, Menghini R, Marx N, Federici M. Mol Metab. 2020. doi:10 [...] Marchetti V, Fabrizi M, Stöhr R, Marino A, Casagrande V, Fiorentino L, Cardelli M, Kappel B, Monteleone I, Garret C, Mauriello A, Monteleone G, Farcomeni A, Burcelin R, Menghini R, Federici M. Cell Rep. 2016 [...] hypercholesterolemic mice. Stöhr R*, Kappel B*, Carnevale D*, Cavalera M, Mavilio M, Arisi I, Fardella V, Cifelli G, Casagrande V, Rizza S, Cattaneo A, Mauriello A, Menghini R, Lembo G, Federici M Mol. Metab

Kaltenborn N, Prange A, Marx R, Niethard FU, Telle R (2005). Bioactivation of inert alumina ceramics by hydroxylation. Biomaterials 26:6151-6157. Fischer H, Hemelik M, Telle R, Marx R (2005). Influence of annealing [...] implant abutments. Dent Mater 27:298-303. Lindner M, Hoeges S, Meiners W, Wissenbach K, Smeets R, Telle R, Poprawe R, Fischer H (2011). Manufacturing of individual biodegradable bone substitute implants using [...] Telle R, Knüchel R, Fischer H (2010). Cytocompatibility of high strength non-oxide ceramics. J Biomed Mater Res (Part A) 93: 67-76. Ebert J, Özkol E, Zeichner A, Uibel K, Weiss Ö, Koops U, Telle R, Fischer