tream kinase TAK1 can be employed to regulate macrophage activity. We identified HNRNPK as regulator of TAK1 mRNA, which does not affect TAK1 gene activity, but directly modulates TAK1 protein synthesis [...] 0241-80-36567 Prof. Dr. rer. nat. Dirk Ostareck Tel.: 0241-80-36568 1) Optimization of small molecules to modulate HNRNPK-controlled TAK1 synthesis in macrophages Summary Macrophage activation through bacterial [...] in vivo . Our innovative approach takes advantage of small molecules to control HNRNPK-TAK1 mRNA binding and TAK1 expression. To optimize suitable molecular components structural analyses and functional

Laube, N. Bornfeld, G. Thumann, P. Walter, W. Mokwa, S. Johnen and G. Roessler (2014), „Development of very large electrode arrays for epiretinal stimulation (VLARS)”,. Biomed Eng Online 13(1): 11. Hirota [...] Qualification and Education 2010 – 2016 Medical studies, RWTH Aachen University, Germany 2014 USMLE Step 1 2014 – 2015 Research stay at Applied Visual Science Center, Osaka University, Japan (Prof. Fujikado) [...] Artificial Vision, Visual Prostheses, Retinal Degeneration, Biomaterials Key Publications Lohmann, T. K. , H. Kanda, T. Morimoto, T. Endo, T. Miyoshi, K. Nishida, M. Kamei, P. Walter and T. Fujikado (2016), „Surgical

transport system in bacterial outer membranes. Nat Struct Mol Biol 19: 506–10, S1 Shen H-H, Leyton DL, Shiota T, Belousoff MJ, Noinaj N, Lu J, Holt SA, Tan K, Selkrig J , Webb CT, et al (2014) Reconstitution of [...] 17: e10188. *shared-first authorship. *co-first Selkrig J , Li N, Hausmann A, Mangan MSJ, Zietek M, Mateus A, Bobonis J, Sueki A, Imamura H, El Debs B, et al (2020) Spatiotemporal proteomics uncovers c [...] human macrophages. PLoS Pathog 18: e1010308 Lahiri S, Kim H, Garcia-Perez I, Reza MM, Martin KA, Kundu P, Cox LM, Selkrig J , Posma JM, Zhang H, et al (2019) The gut microbiota influences skeletal muscle

y] Chen X, Kalbacher H und Gründer S The tarantula toxin Psalmotoxin 1 inhibits Acid Sensing Ion Channel (ASIC) 1a by increasing ist apparent H+ affinity. J. Gen. Physiol . 126 (1), 71-79 (2005) [demonstration [...] (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry. Proc. Natl. Acad. Sci. USA , 111(2), 8281-8286 (2014) [demonstration of a trimeric stoichiometry for ASICs; demonstration that the 1a/2a heteromer [...] heteromer exists in two stoichiometries] Reimers C, Lee C-H, Kalbacher H, Tian Y, Hung C-H, Schmidt A, Prokop L, Kauferstein S, Mebs D, Chen C-C und Gründer S Identification of the a cono-RFamide from the

Hämatopoese Ausgewählte Publikationen Kirschner M *, Schemionek M*, Schubert C, Chatain N, Sontag S, Isfort S, Ortiz-Brüchle N, Schmitt K, Krüger L, Zerres K, Zenke M, Brümmendorf TH, Koschmieder S; Dissecting [...] Wolf D, Maintz C, Hänel M, Gattermann N, Gökkurt E, Platzbecker U, Hollburg W, Göthert JR, Parmentier S, Lang F, Hansen R, Isfort S, Schmitt K, Jost E, Serve H, Ehninger G, Berdel WE, Brümmendorf TH, [...] Glimm H, Hacker UT, Heinemann V, Illert AL, Keilholz U, Kindler T, Kirschner M , Schilling B, Siveke JT, Schroeder T, Tischler V, Wagner S, Weichert W, Zips D, Loges S Eur J Cancer. 2020 Aug;135:1-7. doi:

characterization of the human bile acid-sensitive ion channel (hBASIC). Pflugers Arch 466, 253-263. Wiemuth D , Sahin H, Lefèvre CM, Wasmuth H, Gründer S. Strong activation of bile acid-sensitive ion channel [...] c acid. Channels (Austin). 2012 Oct 12;7(1). [Epub ahead of print] Wiemuth D , van de Sandt L, Herr R, Gründer S. (2012) Transient receptor potential N (TRPN1) from Xenopus interacts with the penta-EF-hand [...] tle P, Snyder PM, McDonald FJ. (2010) Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS One ,

S, Gayrard N, Salem S, Bhargava S, Jankowski V, Jover B, Notarnicola C, Noels H, van der Vorst E.P.C., Kuppe C, Wolf M, Goettsch C , Theelen W, Bruck H, Fliser D, Loscalzo J, Wu Z, Marx N, Zidek W, Argiles [...] 2016;19:628-642. Iwata H, Goettsch C , Sharma A, Ricchiuto P, Goh WWB, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabasi AL, Boothby N, Aikawa E, Singh SA, Aikawa [...] Schunk SJ, Thirup S, Winther S, Bottcher M, Nyegard M, Nykjaer A, Kramann R, Kaesler N, Jankowski J, Floege J, Marx N, Goettsch C . Carbamylated sortilin associates with cardiovascular calcification in

Das Institut für Physiologie hat die Lehre und Forschung in Physiologie zur Aufgabe. Wir beteiligen uns engagiert am Aachener Modellstudiengang Medizin, in dem bereits in den ersten Semestern eine bessere Verzahnung der vorklinischen und klinischen Elemente angestrebt wird.

set-up for implementing a semi-automated Mouse Grimace Scale scoring (Part 1). Lab Anim. 2020;54(1): 83-91 (Impact Factor (2018)=1.117, Typ=Article; Journal Article) Ernst L, Kopaczka M, Schulz M, Talbot [...] 2020;54(1): 92-98 (Impact Factor (2018)=1.117, Typ=Article; Journal Article) Ernst L, Kopaczka M, Schulz. M, Talbot SR, Struve B, Häger C, Bleich A, Durst M, Jirkof P, Arras M, van Dijk RM, Miljanovic N, Potschka [...] Kadaba Srinivasan P, Tanaka H, Fukushima K, Tolba R Measurement of corticosterone in mice: a protocol for a mapping review. Lab Anim. 2020;54(1): 26-32 (Impact Factor (2018)=1.117, Typ=Review; Journal Article)

Marx N, Jankowski J and Noels H. Platelet Function in CKD: A Systematic Review and Meta-Analysis. J Am Soc Nephrol . 2021. Baaten C, Schroer J, Floege J, Marx N, Jankowski J, Berger M and Noels H. Platelet [...] d vascular grafts with transformative (1)H/(19)F MRI traceable scaffolds. Biomaterials . 2024;311:122669. Mina IK, Mavrogeorgis E, Siwy J, Stojanov R, Mischak H, Latosinska A and Jankowski V. Multiple [...] Marx N, Speer T, Boor P, Jankowski J and Noels H. Chemokine CCL9 Is Upregulated Early in Chronic Kidney Disease and Counteracts Kidney Inflammation and Fibrosis. Biomedicines . 2022;10. Bohler H, Orth-Alampour