inhibits the rP2X1 and rP2X3 receptors. Molecular docking studies, site-directed mutagenesis and concentration-response analysis revealed that ATA binds to the negative allosteric site of the hP2X3 receptor [...] Diclofenac was the most effective antagonist. Due to their involvement in nociception, inhibition of hP2X3R and hP2X2/3R by micromolar concentrations of diclofenac, which are rarely reached in the human body [...] molecular-docking of ATA and AF-219 (a known P2X3R antagonist) into the negative allosteric site of the hP2X3R. In another study we have demonstrated the inhibition of the human P2X3 receptor by various no

Das Institut für Pharmakologie und Toxikologie der Uniklinik RWTH Aachen erforscht, wie Arzneimittel wirken.

. Anästh Intensivmed 2015;56:257-261, Aktiv Druck & Verlag GmbH . Marx G, Markewitz A, van Aalst G. Telemedizin in der Intensivmedizin. S1 Leitlinie der DGAI (001-034) . Arbeitsgemeinschaft der Wissen [...] Englbrecht J, Dohmen S, Gottschalk A, Haverkamp M, Hempen A, Flügel-Bleienheuft C, Bause D, Schulze-Steinen H, Rademacher S, Kistermann J, Hoch S, Beckmann HJ, Lanckohr C, Lowitsch V, Peine A, Juzek-Kuepper F, [...] TELnet@NRW . ains · Anästhesiologie · Intensivmedizin. 56. 52-59. 10.1055/a-1288-4587. Dohmen S, Pecquet N . Positive Effekte von Telekonsultation bei der Versorgung intensivmedizinischer Covid-19 Patienten

Culemann R, Eulenburg C, Adams J, Nitzsche H, Prange A, Kümmel S, Grischke EM, Forstbauer H, Braun M, Potenberg J, von Schumann R, Aktas B, Kolberg-Liedtke C, Harbeck N, Kuhl CK, Nitz U Magnetic resonance imaging [...] Schumacher C, Grischke EM, Forstbauer H, Braun M, Christgen M, Adams J, Nitzsche H, Just M, Fischer HH, Aktas B, Potenberg J, von Schumann R, Kolberg-Liedtke C, Harbeck N, Kuhl CK, Nitz U Early response by [...] Kuhl CK, Engelke H, Bettermann G, Keil S Factors That Drive Heterogeneity of Response-to-Treatment of Different Metastatic Deposits Within the Same Patients as Measured by RECIST 1.1 Analyses. In: Academic

Suppl 1:123-39. Frühere Publikationen Ezan J., Lasvaux L., Gezer A., Novakovic A., May-Simera H., Belotti E., Lhoumeau AC., Birnbaumer L., Beer-Hammer S., Borg JP., Le Bivic A., Nürnberg B., Sans N., Mo [...] Hippe HJ., Ludde M., Schnoes K., Novakovic A., Lutz S., Katus HA., Niroomand F., Nürnberg B., Frey N., Wieland T (2013). Competition for Gbg dimers mediates a specific cross-talk between stimulatory and [...] Drechsler D., Günter M., Hochweller K., Novakovic A., Beer-Hammer S., Samstag Y., Hämmerling GJ., Garbi N., Autenrieth IB. Depletion of Dendritic Cells Enhances Innate Anti-Bacterial Host Defense through Modulation

Jugendpsychiatr Psychother 2017;45(5):381–90. Graap H et al. The needs of carers of patients with anorexia and bulimia nervosa. Eur Eat Disord Rev 2008;16(1):21–9. Hay PJ et al. Inpatient versus outpatient [...] 415-27 Micali N et al. The incidence of eating disorders in the UK in 2000–2009: findings from the General Practice Re-search Database. BMJ Open. 2013;3(5):e002646. Mitrofan O, Petkova H, Janssens A, Kelly [...] Years: Ex-pressed Emotions and Depressive Symptoms in Caregivers. Eur Eat Dis Rev. 2017;25(1):44–51. Sjølie H et al. Crisis resolution and home treatment: structure, process, and outcome - a literature

heterologous expression of ion channels in Xenopus laevis oocytes or mammalian cells (e.g. HEK293, 1321N1 astrocytoma cells), two-electrode voltage-clamp (TEVC) and patch-clamp electrophysiology, automated [...] Bebrivenski N, Neuhof C, Detro-Dassen S, Hautvast P, Benasolo CA, Meents J, Machtens JP, Schmalzing G, Lampert A (2020) Uncoupling sodium channel dimers restores the phenotype of a pain-linked Na(v) 1.7 channel [...] currents induced by an insecticide in human cardiac Nav1.5. Toxicol Appl Pharmacol. 397:115010. https://www.ncbi.nlm.nih.gov/pubmed/32302602/ Obrecht AS, Urban N, Schaefer M, Rose A, Kless A, Meents JE, Lampert

2018; 57(S 01): e92-e105. H. Fröhlich, R. Balling, N. Beerenwinkel,, O. Kohlbacher, S. Kumar, Th. Lengauerm M.H. Maathuis, Y. Moreau, S.A. Murphy, T.M. Przytycka, M. Rebhan, H. Röst, A. Schuppert, M. Schwab [...] CSNK1A1 in clonal expansion. Blood Adv. 2022 Mar 22;6(6):1780-1796. doi: 10.1182/bloodadvances.2021006061. PMID: 35016204; PMCID: PMC8941465. Jefri M, Zhang X, Stumpf PS, Zhang L, Peng H, Hettige N, Theroux [...] Görlitz, L., H.Ellinger-Ziegelbauer, H.-J. Ahr, A Schuppert (2010): An elastic network theory to identify characteristic stress response genes, Comp.Biol.Chem. 34 , 193-202. R.Ummanni, F.Mundt, H.Pospisil

Yokoyama H, Moschopoulou A, De S, Bono F, Hipp K, Schäffer E, Antonin W (2017). Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics . Scientific Reports. 7(1): 9996. doi: [...] Cell Biol 40, 15–22. Moreno-Andrés D, Yokoyama H, Scheufen A, Holzer G, Lue H, Schellhaus AK, Weberruss M, Takagi M, Antonin W (2020). VPS72/YL1-Mediated H2A.Z Deposition Is Required for Nuclear Reassembly [...] much less studied. One of these GTPase, DRG1 (developmental regulated GTPase 1) will be analyzed in this project, especially its GTPAse activity: How is DRG1 activity affected by the different domains

Wie werden Sie Doktorand? 1. Bewerbung Sie bewerben sich in kurzer schriftlicher Form bei Frau Prof. Dr. N. Kuth (Bewerbungsschreiben und Lebenslauf), Leiterin des Lehrgebietes Allgemeinmedizin 2. Festlegung [...] r wissenschaftlicher Arbeit für Doktoranden in der Medizin und Zahnmedizin Verlag W. Kohlhammer GmbH Stuttgart, Berlin, Köln 2004 ISBN: 3-17-016642-5 Schaaf, Christian P. Mit Vollgas zum Doktor. Promotion [...] Martin; Schaaf, Ludwig: Praktische Tipps für die Medizinische Doktorarbeit Verlag W. Kohlhammer GmbH Stuttgart, Berlin. 2000 ISBN: 3-17-016642-5