Die Epileptologie in Aachen beschäftigt sich mit der Untersuchung von genetischen Epilepsien mit dem Ziel der Entwicklung neuer Therapiestrategien.

Scientific reports , 12(1), [7160]. https://doi.org/10.1038/s41598-022-11175-y Strudthoff, L., Lüken, H., Jansen, S. V., Petran, J., Schlanstein, P. C., Schraven, L., Schürmann, B. J., Steuer, N., Wagner, G., [...] Alveolar-capillary Basement Membrane Mimics. Advanced Biology 2021, n/a (n/a), 2000427. Obstals, F.; Witzdam, L.; Garay-Sarmiento, M.; Kostina, N. Y.; Quandt, J.; Rossaint, R.; Singh, S.; Grottke, O.; Rodrig [...] Alveolar-capillary Basement Membrane Mimics. Advanced Biology 2021, n/a (n/a), 2000427. Obstals, F.; Witzdam, L.; Garay-Sarmiento, M.; Kostina, N. Y.; Quandt, J.; Rossaint, R.; Singh, S.; Grottke, O.; Rodrig

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Dobrowolny H, Lagopoulos J, Hatton SN, Hickie IB, Carballedo A, Brooks SJ, Vuletic D, Uhlmann A, Veer IM, Walter H, Bülow R, Völzke H, Klinger-König J, Schnell K, Schoepf D, Grotegerd D, Opel N, Dannlowski [...] Healthy Volunteers. Frodl T , Stauber J, Schaaff N, Koutsouleris N, Scheuerecker J, Ewers M, Omerovic M, MD, Opgen-Rhein M, Hampel H, Reiser M, Möller H-J, Meisenzahl E. Acta Psychiatrica Scandinavica. [...] Disorders. JAMA Psychiatry. 2021 Jan 1;78(1):47-63. Erratum in: JAMA Psychiatry. 2021; 78(1):112. (Impact Factor: 21.596) PMID: 32857118. Calvo A, Roddy DW, Coughlan H, Kelleher I, Healy C, Harley M, Clarke

omoter LOH Status 1p, 19q-Fragmentanalyse Sequenzierung von BRAF, Ex 15 Sequenzierung IDH1, Ex. 4 Sequenzierung IDH2, Ex. 4 TERT-Promoter H3F3A, Ex. 2 HIST1H3B, Ex. 1 HIST1H3C, Ex. 1 Next-Generation Sequencing [...] (CD45) CD1a CD3 CD4 CD8 CD10 CD20 (L26) CD30 CD31 CD34 CD45 R0 CD68 CD79a CD138 IgA IgD IgE IgG IgM Ƙ-Leichtkette λ-Leichtkette GFAP Protein S100 Vimentin α B Crystallin HVL-Hormone SF1 Pit1 TPit α-Fetoprotein [...] α-Fetoprotein β-hCG PLAP CD117 c-kit CD99 (MIC2) Trimethyl-Histone H3 (Lys27) Dystrophin 1 Dystrophin 2 Dystrophin 3 α-Sarkoglykan β-Sarkoglykan γ-Sarkoglykan δ-Sarkoglykan α-Dystroglykan β-Dystroglykan Merosin

Heidenreich O. Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo. Leukemia. 2009 Jan;23(1):188-90. doi: 10.1038/leu.2008.157. Epub 2008 Jun 12. No abstract available. PubMed [...] Quinete N, Müller JP, Stingl J, Bertram J, Schettgen T, Kraus T, Ziegler P . Partial dechlorination of 2,4,4'-trichlorobiphenyl (PCB 28) mediated by recombinant human CYP1A2. Arch Toxicol. 2024 Jan;98(1):159-163 [...] Arch Toxicol. 2017 Jan;91(1):289-300. doi: 10.1007/s00204-016-1725-8. Epub 2016 May 5. PubMed [citation] PMID: 27146145, PMCID: PMC5225163 Weiss M, Ahrend H, Grossebrummel H, Ziegler P, Brandenburg LO

Swinnen JV, Noels H, Jankowski J, Lebherz C, Boor P, Marx N, Lehrke M.Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166825. doi: 10.1016/j.bbadis.2023.166825. Epub 2023 Aug 1.PMID: 37536502 The [...] GD, Verma S, Marx N, Lehrke M.Biochim Biophys Acta Mol Basis Dis. 2020 Aug 1;1866(8):165807. doi: 10.1016/j.bbadis.2020.165807. Epub 2020 Apr 28.PMID: 32353614 Glucagon-Like Peptide 1 and Its Cleavage Products [...] Boor P, Kramann R, Ghesquiere B, Lebherz C, Marx N, Lehrke M.Diabetes Obes Metab. 2022 Nov;24(11):2263-2272. doi: 10.1111/dom.14814. Epub 2022 Aug 1.PMID: 35801343 Empagliflozin improves left ventricular

Thiele H, Altmüller J, Jabbari K, Ruppert AK, Jurkowski W, Lal D, Rusconi R, Cestèle S, Terragni B, Coombs ID, Reid CA, Striano P, Caglayan H, Siren A, Everett K, Møller RS, Hjalgrim H, Muhle H, Helbig [...] doi: 10.1007/s40262-015-0267-1. PMID: 25860377. Wolking S, Becker F, Bast T, Wiemer-Kruel A, Mayer T, Lerche H, Weber YG. Focal epilepsy in glucose transporter type 1 (Glut1) defects: case reports and a [...] express altered fly genes or humanized genes. We focus on synaptic epilepsy genes, such as AP2M1 , STXBP1, and STX1B that have a high degree of orthology with fly genes . We use behavioral experiments, Cal

Publikationen im Institut für Pathologie der Uniklinik RWTH Aachen aus der AG Molekulare Onkologie.